Protective effects of acetyl-l-carnitine after brain ischemia

Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia

The aim of the present study was an evaluation of the possible protective effect of acetyl-l-carnitine (essential nutrient) after brain ischemia (insufficient supply of blood to the brain). These experiments were performed by means of animal models (rats). The results showed that acetyl-l-carnitine administration can restore brain functionality. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Kocsis K, Knapp L, Gellért L, Oláh G, Kis Z, Takakuwa H, Iwamori N, Ono E, Toldi J, Farkas T. Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia. Neuroscience. 2014 Jun 6;269:265-72.


Leave a Reply