Alpha-tocopherol in the brain tissue preservation of stroke-prone spontaneously hypertensive rats
This study aimed to investigate the influence of alpha-tocopherol (vitamin E) in the preservation of brain tissue. After vitamin E administration, the researchers evaluated various parameters (body weight, diuresis, food and water intake, nervous system responses and brain tissue analysis) in hypertensive rats. The results suggested that vitamin E can prevent stroke and maintain brain functionalities. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Murad LB, Guimarães MR, Paganelli A, de Oliveira CA, Vianna LM. Alpha-tocopherol in the brain tissue preservation of stroke-prone spontaneously hypertensive rats. J Physiol Biochem. 2014 Mar;70(1):49-60.