Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA.
This pilot study was conducted by the Mayo Clinic / Foundation in Minnesota, USA, to explore the effect of American ginseng, a plant that grows on forest floors in Eastern North America, on cancer-related fatigue. Over 8 weeks, an unspecified number of adults with a history of cancer-related fatigue received American ginseng in doses of 750, 1,000, or 2,000 mg/day or a placebo in twice daily dosing. At the end of the study, it turned out that twice as many patients on ginseng perceived a benefit, as compared to those on placebo. The authors concluded that American ginseng seems to be effective against cancer-related fatigue at doses of 1,000–2,000 mg/day. More details can be found in the study.
Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA, Figueras C, Duane S, Mattar B, Liu H, Atherton PJ, Christensen B, Loprinzi CL. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer. 2010 Feb;18(2):179-87.