Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial
This study tested how the supplementation with antioxidant vitamins can be critical after stroke. 96 stroke patients were assigned to receive either vitamin E and vitamin C or B-group vitamins (B2, B6, B12), both vitamins together or no supplementation for 14 days. The results showed that antioxidant supplementation with or without B-group vitamins had beneficial effects such as the reduction of inflammation after stroke. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Ullegaddi R, Powers HJ, Gariballa SE. Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial. JPEN J Parenter Enteral Nutr. 2006 Mar-Apr;30(2):108-14.