Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C deficient mice
These two studies examined the effect of vitamin C supplementation on metastasis and tumor growth, for skin cancer and breast cancer, in mice that cannot produce endogenous vitamin C. During the study, the food and water given to a group of 36-38 weeks old female mice was supplemented with vitamin C for four weeks prior to, and for two weeks after, the injection of cancer cells. The food and water of the control group was not supplemented. The results showed that metastasis, tumor growth and inflammation markers were inhibited by vitamin C supplementation. In addition, there was an increased encapsulation of the skin and breast cancer tumors. Further details can be found in the study.
Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M. Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice. Int J Oncol. 2013 Jan;42(1):55-64.