Low vitamin D levels are associated with high mortality in stroke patients

Association between serum concentration of vitamin D and 1-year mortality in stroke patients

This study evaluated the association between vitamin D levels and 1-year mortality in 382 stroke patients. Vitamin D concentration was measured and clinical information were collected. The results suggested that low vitamin D levels can be associated with higher mortality at 1 year in patients <75 years old. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Daubail B, Jacquin A, Guilland JC, Khoumri C, Aboa-Eboulé C, Giroud M, Béjot Y. Association between serum concentration of vitamin D and 1-year mortality in stroke patients. Cerebrovasc Dis. 2014;37(5):364-7.



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