B vitamins slow cognitive impairment

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.

Homocysteine, an amino acid found in the blood, is a risk factor for dementia and mild cognitive impairment (MCI), a possible early stage of dementia that can involve problems with memory, language, thinking and judgment that are greater than normal age-related changes. This study evaluated whether blood levels of homocysteine can be lowered by supplementing B vitamins, thereby slowing the accelerated rate of mental decline in patients with MCI . 271 MCI participants were given either folic acid, vitamin B12 and vitamin B6 or a placebo for 24 months. The results showed that treatment with B vitamins lowered homocysteine levels and slowed the rate of mental decline in patients with mild cognitive impairment. Further details can be found in the study.
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010 Sep 8;5(9):e12244.



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