B vitamins slow mental decline

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial.

Homocysteine, an amino acid found in the blood, represents a risk factor for Alzheimer's disease. This study evaluated the relationship among homocysteine, Alzheimer's disease and levels of B vitamins in the blood. 266 participants with cognitive (mental) impairment were given either folic acid, vitamin B12 and vitamin B6 or a placebo for 2 years. The results showed that B vitamins slowed cognitive decline in patients with cognitive impairment, in particular in those with elevated homocysteine. Further details can be found in the study.
de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012 Jun;27(6):592-600.


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