Coenzyme Q10 as an effective therapy in heart failure

Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.

This study of cells and tissues discussed the relationship between the severity of heart muscle disease (cardiomyopathy) and coenzyme Q10 deficiency. To this end, the heart muscle tissue and blood of 43 patients were examined after a routine cardiac catheterization. The patients were then divided into degrees of severity (according to the guidelines of the New York Heart Association). The higher the severity of heart failure was, the lower were not only the Q10 levels in the blood, but also those measured in the heart muscle tissue. Subsequently, five patients received supplementation with Q10 for a period of two to eight months. The following control examination (cardiac catheterization) showed a significant increase in coenzyme Q10 levels in the heart muscle tissue. Blood levels of coenzyme Q10 were also increased. As the importance of coenzyme Q10 for the energy supply of cells is indisputable, this study shows that Q10 supplementation can fight the cause of heart muscle disease at cellular level. Further details can be found in the study.
The heart is the “motor” of our body, contracting about 80,000 times a day to pump the blood through our circulatory system. It is the mechanically the most active organ of our body. The actual “work” is performed by billions of muscle cells that contract at the same time to form the heartbeat. And just like in a car, the biological motor “heart” needs energy to function properly. Micronutrients are the most important carriers of biological energy for an optimum contraction of the heart muscle cells. A long-term dietary deficiency of micronutrients leads to an insufficient contraction of the heart muscle cells, to a suboptimal pumping function of the heart and eventually to heart failure (cardiomyopathy). Typical heart failure symptoms include shortness of breath, edema and chronic fatigue, making everyday activities such as house cleaning, walking or going to the supermarket very difficult.
K Folkers, S Vadhanavikit, and S A Mortensen. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A. 1985 Feb; 82(3): 901–904.



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