Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion
The present study evaluated the benefits of a combination therapy in the treatment of ischemic stroke (insufficicient supply of blood to the brain). It was found that the combination of resveratrol and lipoic acid (natural antioxidants compounds) can provide significant protection in rats. The researchers concluded that this antioxidant therapy presents opportunities for addressing ischemia-induced damage in patients with ischemic episodes. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Saleh MC, Connell BJ, Rajagopal D, Khan BV, Abd-El-Aziz AS, Kucukkaya I, Saleh TM. Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion. PLoS One. 2014 Jan 31;9(1):e87865.