Coenzyme Q10 as treatment for cardiomyopathy

A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.

One hundred and forty-three (143) cases of chronic, stable, non-secondary, non-hypertrophic cardiomyopathy, 98% of whom were in NYHA Classes III and IV, were given 100 mg of coenzyme Q10 orally in addition to their conventional medical programme in an open-label long-term study.
Blood CoQ10 levels, clinical status, myocardial function and survival have been recorded now for almost 6 years.
Mean control/CoQ10 levels of 0.85 micrograms/ml rose to 2 micrograms/ml in 3 months and remained stable at that level.
Mean ejection fraction of 44% measured by systolic time interval analysis rose to 60% within 6 months and stabilized at that level with 84% of patients showing statistically significant improvement.
Eighty-five percent of patients improved by one or two NYHA Classes.
Survival figures were encouraging with an 11.1% mortality in 12 months and 17.8% mortality in 24 months, comparing favourably with several reports in the literature.
There was no positive evidence of toxicity or intolerance in a total of 368.9 patient-years of exposure.
Coenzyme Q10 is safe and effective long-term therapy for chronic cardiomyopathy.
The heart is the “motor” of our body, contracting about 80,000 times a day to pump the blood through our circulatory system. It is the mechanically the most active organ of our body. The actual “work” is performed by billions of muscle cells that contract at the same time to form the heartbeat. And just like in a car, the biological motor “heart” needs energy to function properly. Micronutrients are the most important carriers of biological energy for an optimum contraction of the heart muscle cells. A long-term dietary deficiency of micronutrients leads to an insufficient contraction of the heart muscle cells, to a suboptimal pumping function of the heart and eventually to heart failure (cardiomyopathy). Typical heart failure symptoms include shortness of breath, edema and chronic fatigue, making everyday activities such as house cleaning, walking or going to the supermarket very difficult.
Langsjoen PH, Langsjoen PH, Folkers K.
A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.
Int J Tissue React. 1990;12(3):169-71.

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