Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
This double-blind, placebo-controlled study focused on the role of pantethine, a substance related to the vitamin B5 molecule, and its possible beneficial effects on patients with lipid metabolism disorders. The scientific basis for this study was provided by the fact that vitamin B5 – a component of coenzyme A – plays a key role in the energy metabolism of the cells. In the study, 29 patients with various lipid metabolism disorders were treated for 8 weeks with either pantethine or a placebo. It was found that in patients with various congenital disorders of lipid metabolism pantethine was able to reduce blood levels of total cholesterol, LDL cholesterol and triglycerides, whilst at the same time increasing HDL cholesterol ("good cholesterol"). Further details can be found in the study.
Lipid disorders are characterized by imbalanced levels of fatty substances (i.e. cholesterol and triglycerides) in the bloodstream. These lipids are carried in the blood stream in form of microscopic round particles, called lipoproteins. Thus, these conditions are also called lipoprotein disorders. There are, generally speaking, two types of cholesterol-transporting lipoproteins: a) the “bad cholesterol” are those lipoproteins that carry cholesterol and other fatty substances to the sites of tissue repair, e.g. in the artery walls; the most common representatives of this group are Low-density-lipoproteins (LDL) and, a newer one, Lipoprotein(a), Lp(a). b) the “good cholesterol” are those lipoproteins that carry cholesterol and other fatty substances away from the sites of tissue repair and transport it back to the liver where it is biologically “burnt” One of the most frequent causes why “bad cholesterol” particles are elevated in the blood stream is micronutrient deficiency. This can be easily explained: A deficiency of vitamins causes structural damage to the artery walls and other organs and the body (liver) reacts with an increased production of “repair factors” like LDL and Lp(a). Because the elevation of these risk factors in the blood is already a reaction damage of our body tissue caused by vitamin deficiency, they are considered “secondary” risk factors.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. Atherosclerosis. 1984 Jan;50(1):73-83.