Anti-inflammatory plant extract Curcumin helps treating osteoarthritis

Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.

The purpose of this study was to examine the effects of curcumin on pro-inflammatory factors such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). IL-1beta and TNF-alpha play a key role in the development of osteoarthritis (OA).The effects of curcumin were studied in human cells treated with IL-1beta and TNF-alpha for up to 72h. The results indicated that curcumin can be considered as a natural anti-inflammatory agent for treating OA through suppression of pro-inflammatory factors. Further details can be found in the study.
Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45.


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