Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells.
In this research the effect of different forms of vitamin E (alpha-, gamma- and delta-tocotrienol) was tested in relation to their ability to inhibit and kill cancer cells. The studies were performed on human lung cancer (adenocarcinoma) and brain tumor cells (glioma). All forms of the vitamin E derivatives tested were able to inhibit and kill cancer cells. The delta-tocotrienol form of vitamin E was found to be especially effective. The authors concluded that the vitamin E forms studied can be considered as an alternative form of chemotherapy. Researchers at the University of Nottingham Malaysia Campus investigated different forms of tocotrienols (Vitamin E) and their effect on human lung- and brain cancer cells. They compared alpha-, gamma- and delta-tocotrienols in their ability to induce cell death in cancer cells (apoptosis). Results showed that delta-tocotrienol was particularly effective and fast working against lung- and brain cancer cells. Therefore the authors conclude that those forms of Vitamin E can be seen as alternative chemotherapeutic agents in the treatment of lung and brain cancers. Further details can be found in the study.
Lim SW, Loh HS, Ting KN, Bradshaw TD, Zeenathul NA. Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. BMC Complement Altern Med. 2014 Dec 6;14:469.