Effect of folic acid for treatment of acute cerebral infarction in rats
This study was performed to test whether folic acid offers protection of the brain tissue against cerebral infarction. In this experiment, rats were divided into control, pre-treatment and treatment groups. All rats suffered from artery occlusion. Pre-treatment and treatment groups were given folic acid suspension daily. The cells brain functionality was evaluated on a daily basis. The researchers concluded that folic acid protects brain tissue against cerebral infarction. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Wang R, Luo L, Zhou B, Abdugeni P, Peng Y, Zhang S. Effect of folic acid for treatment of acute cerebral infarction in rats. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Sep;33(9):1321-4.