Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris
This placebo-controlled randomized double-blind crossover study examined the effect of coenzyme Q10 on the physical capacity of angina pectoris patients. For this purpose, 12 patients with an average age of 56 years received either oral coenzyme Q10 or ineffective placebos over a period of 4 weeks. At the beginning and at the end of the study, the patients underwent multistage treadmill exercise tests. It turned out that the number of angina pectoris attacks were halved under coenzyme Q10 administration. Additionally, the exercise duration on the treadmill – without experiencing an angina attack – was significantly increased. The authors concluded that coenzyme Q10 can be an effective support in the treatment of angina pectoris. Further details can be found in the study.
The underlying disease process of coronary artery disease (CAD) is called arteriosclerosis. This process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of the wall. The arteriosclerotic plaques that – with time – narrow the blood flow in the coronary arteries is essentially an overshooting repair process for the vitamin-deficient coronary artery wall. A heart attack occurs when the already narrowed artery is clogged and the supply of oxygen and nutrients to billions of heart muscle cells is interrupted. Angina pectoris. Angina pectoris is the typical alarm signal for an increased risk of heart attack. Angina pectoris typically manifests as a sharp pain in the middle of the chest, which frequently radiates into the left arm, but can also manifest itself in other (untypical) symptoms.
Kamikawa T, Kobayashi A, Yamashita T, Hayashi H, Yamazaki N. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. 1985 Aug 1;56(4):247-51.