High-dose thiamine improves fatigue after stroke: a report of three cases
This study investigated the link among vitamin B1, fatigue and stroke. Three patients with stroke who also experienced fatigue were recruited and the therapy with high-dose vitamin B1 was started.The therapy led to an appreciable improvement of fatigue. This observation suggests that post-stroke fatigue could be the manifestation of vitamin B1 deficiency. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Costantini A, Pala MI, Catalano ML, Notarangelo C, Careddu P. High-dose thiamine improves fatigue after stroke: a report of three cases. J Altern Complement Med. 2014 Sep;20(9):683-5.