High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects.
This placebo-controlled double-blind study evaluated the efficacy of the micronutrient L-carnitine in patients with cardiac arrhythmias. The purpose of the study was to investigate whether the administration of high doses of L-carnitine decreases severe cardiac arrhythmia (ventricular arrhythmias) in patients with acute myocardial infarction. 56 patients with an acute heart attack were enrolled in the study. Half of them received 100 mg L-carnitine and the other half a placebo administered intravenously. The study results showed that the incidence of cardiac arrhythmias was reduced as a result of the L-carnitine intake. For more details see the study.
The underlying disease process of coronary artery disease (CAD) is called arteriosclerosis. This process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of the wall. The arteriosclerotic plaques that – with time – narrow the blood flow in the coronary arteries is essentially an overshooting repair process for the vitamin-deficient coronary artery wall. A heart attack occurs when the already narrowed artery is clogged and the supply of oxygen and nutrients to billions of heart muscle cells is interrupted. Angina pectoris. Angina pectoris is the typical alarm signal for an increased risk of heart attack. Angina pectoris typically manifests as a sharp pain in the middle of the chest, which frequently radiates into the left arm, but can also manifest itself in other (untypical) symptoms.
Rizzon P, Biasco G, Di Biase M, Boscia F, Rizzo U, Minafra F, Bortone A, Siliprandi N, Procopio A, Bagiella E. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Eur Heart J. 1989 Jun;10(6):502-8.