Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-culturalepidemiology.
This study involving middle-aged men from 16 European countries, examined the relationship between vitamin E levels in the blood and the mortality from heart attacks (ischemic heart disease). Of all studied risk factors, including cholesterol levels, blood pressure and other known risk factors, low vitamin E levels were associated most strongly with increased heart attack rates. A reduction of other risk factors had an additional positive impact on the reduction of heart attack risk. However, taken alone, these factors showed no significant relationship. Further details can be found in the study.
The underlying disease process of coronary artery disease (CAD) is called arteriosclerosis. This process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of the wall. The arteriosclerotic plaques that – with time – narrow the blood flow in the coronary arteries is essentially an overshooting repair process for the vitamin-deficient coronary artery wall. A heart attack occurs when the already narrowed artery is clogged and the supply of oxygen and nutrients to billions of heart muscle cells is interrupted. Angina pectoris. Angina pectoris is the typical alarm signal for an increased risk of heart attack. Angina pectoris typically manifests as a sharp pain in the middle of the chest, which frequently radiates into the left arm, but can also manifest itself in other (untypical) symptoms.
Gey KF, Puska P, Jordan P, Moser UK. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr. 1991 Jan;53(1 Suppl):326S-334S.