Magnesium decreases frequency of cardiac arrhythmias after bypass surgery

Magnesium administration and dysrhythmias after cardiac surgery. A placebo-controlled, double-blind, randomized trial

This placebo-controlled randomized double-blind study examined whether magnesium is able to prevent postoperative cardiac arrhythmias. 100 patients of a university hospital were divided into two groups. One group received an intravenous infusion of 2 grams of magnesium, the other group was given an ineffective placebo. It was found that magnesium intake was able to reduce the incidence of postoperative arrhythmias by half. Simultaneously, the stroke volume of the heart was increased in these patients. Further details can be found in the study.
Coronary bypass operation. A coronary bypass operation becomes necessary if one or more coronary arteries have developed severe atherosclerotic deposits that threaten to clog the arteries and cause a heart attack. In order to avoid a heart attack, a coronary bypass operation is frequently performed. Surgically, a bypass is constructed around the atherosclerotic deposits in order to guarantee unrestricted blood flow to all parts of the heart muscle. The overall success of a coronary artery bypass operation is threatened by two main problems: blood clots and atherosclerotic deposits. Coronary angioplasty. Coronary angioplasty is the approach of removing atherosclerotic deposits mechanically. This approach generally involves an inflatable balloon or, more recently, laser or scraping methods. All angioplasty procedures damage the inside of the coronary arteries. In more than 30% of all cases a restenosis occurs, leading to the clogging of the coronary artery within a time as short as six months. The most serious complications during the procedure is the rupturing of the wall of the coronary artery, requiring immediate bypass surgery. Following the procedure, blood clots and small pieces of artery wall tissue can lead to a clogging of the coronary artery. Long-term complications include the overgrowth of scar tissue inside the coronary artery and the continued development of atherosclerotic deposits.
England MR, Gordon G, Salem M, Chernow B. Magnesium administration and dysrhythmias after cardiac surgery. A placebo-controlled, double-blind, randomized trial. JAMA. 1992 Nov 4;268(17):2395-402.


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