Multivitamin use and risk of stroke mortality: the Japan collaborative cohort study
This study examined the association between multivitamin use and risk of death from stroke. A total of 72,180 Japanese men and women who were free from cardiovascular diseases and cancers at the beginning of the study were enrolled. Lifestyles, including multivitamin use, were collected using questionnaires. The results showed that multivitamin use, particularly frequent use, was associated with reduced risk of death from stroke among Japanese people with lower intake of fruits and vegetables. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Dong JY, Iso H, Kitamura A, Tamakoshi A. Multivitamin use and risk of stroke mortality: the Japan collaborative cohort study. Stroke. 2015 May;46(5):1167-72.