Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients With Heart Failure
This research determined whether oral supplementation of the natural amino acid L-arginine can augment blood flow and improve health status in patients with heart failure (heart inability to pump an adequate amount of blood). For 6 weeks, 15 subjects were given oral L-arginine and placebo capsules in random sequence. The results showed that L-arginine had beneficial effects in patients with heart failure. Further details can be found in the study.
The heart is the “motor” of our body, contracting about 80,000 times a day to pump the blood through our circulatory system. It is the mechanically the most active organ of our body. The actual “work” is performed by billions of muscle cells that contract at the same time to form the heartbeat. And just like in a car, the biological motor “heart” needs energy to function properly. Micronutrients are the most important carriers of biological energy for an optimum contraction of the heart muscle cells. A long-term dietary deficiency of micronutrients leads to an insufficient contraction of the heart muscle cells, to a suboptimal pumping function of the heart and eventually to heart failure (cardiomyopathy). Typical heart failure symptoms include shortness of breath, edema and chronic fatigue, making everyday activities such as house cleaning, walking or going to the supermarket very difficult.
Thomas S. Rector, Alan J. Bank, Kathleen A. Mullen, Linda K. Tschumperlin, Ronald Sih, Kamalesh Pillai, Spencer H. Kubo. Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients With Heart Failure. Circulation 1996; 93: 2135-2141.