Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice
The present study aimed at investigating the protective effects of retinol palmitate (analog of vitamin A) against brain ischemia (insufficient supply of blood to the brain). By means of an animal model (mice) it was shown that retinol palmitate can prevent brain ischemia. The researchers concluded that retinol palmitate could be a treatment option for human brain infarction. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Shimada J, Taniguchi J, Mori M, Sato Y, Takuwa H, Ito H, Kuwabara S. Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice. Exp Neurol. 2013 Sep;247:182-7.