Serum Vitamin D Status as a Predictor of Prognosis in Patients with Acute Ischemic Stroke
The purpose of this study was to determine the association between vitamin D levels and stroke. A total of 818 stroke patients with a mean age of 66 years were enrolled in this study. Vitamin D levels were significantly higher in patients with good treatment results than in those with poor treatment results. This study suggested that vitamin D levels can predict the treatment outcome in patients with stroke. Further details can be found in the study.
As in coronary artery disease, the underlying disease process for cerebrovascular disease –the narrowing of the arteries that supply blood to the brain – is arteriosclerosis. Here too, the process starts with a weakening of the blood vessel walls, most frequently caused by an insufficient dietary intake of vitamins and other micronutrients. This leads to an underproduction of collagen and other reinforcement molecules in the artery walls and to the initiation of a repair process to compensate for the growing instability of these walls. The arteriosclerotic plaques that – with time – narrow the blood flow in the neck (carotid) arteries or brain (cerebral) arteries is essentially an overshooting repair process for the vitamin-deficient artery wall. A stroke occurs when the already narrowed arteries are clogged and the supply of oxygen and nutrients to billions of brain cells is interrupted, causing permanent damage.
Park KY, Chung PW, Kim YB, Moon HS, Suh BC, Won YS, Kim JM, Youn YC, Kwon OS. Serum Vitamin D Status as a Predictor of Prognosis in Patients with Acute Ischemic Stroke. Cerebrovasc Dis. 2015;40(1-2):73-80.