Thiamine and Alzheimer's Disease
This study evaluated the effects of thiamine (vitamin B1) in patients with Alzheimer's disease. Patients received either vitamin B1 or an ineffective placebo for 3 months. 11 participants completed the study. The results demonstrated that vitamin B1 supplementation improved the mental function of Alzheimer’s patients, as compared to those taking a placebo. More details can be found in the study.
John P. Blass, Patricia Gleason, Dorothea Brush, Pompeo DiPonte, Howard Thaler. Thiamine and Alzheimer's Disease. Arch Neurol. 1988;45(8):833-835.