Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Seizures, a symptom of Alzheimer's disease, are able to accelerate brain dysfunction. According to research, vitamin C deficiency is an important cause of seizures. This study tested the susceptibility to seizures in mice with Alzheimer´s disease and low concentrations of vitamin C in the brain. The researchers found that low vitamin C concentrations increased the susceptibility to seizures. It was therefore concluded that adequate vitamin C levels may decrease the risk for conditions that are associated with Alzheimer's disease. More details can be found in the study.
Warner TA, Kang JQ, Kennard JA, Harrison FE. Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acidtransport and Alzheimer's disease. Epilepsy Res. 2015 Feb;110:20-5.