Vitamin C is essential for bone maintenance

Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency.

This study evaluated the relationship between vitamin C deficiency and the development of fractures caused by osteoporosis (“spontaneous” fractures). Analyses of vitamin C-deficient mice revealed a reduction of bone formation (process by which new bone is produced) by more than 90%. The researchers concluded that vitamin C is essential for the maintenance of bone health. Further details can be found in the study.
Mohan S, Kapoor A, Singgih A, Zhang Z, Taylor T, Yu H, Chadwick RB, Chung YS, Donahue LR, Rosen C, Crawford GC, Wergedal J, Baylink DJ. Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. J Bone Miner Res. 2005 Sep;20(9):1597-610.



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