High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice.
The progression of Alzheimer's disease is linked to two factors: the breakdown of the blood-brain barrier (highly selective barrier that separates blood from the brain) and the dysfunction of mitochondria (organelles placed in the cells that are involved in energy production). Vitamin C has been reported to function as a modulator of blood-brain barrier integrity and mitochondria. Against this background, the present study investigated the effects of vitamin C supplementation in mice with Alzheimer´s disease. The mice were maintained on either low (0.66 g/l) or high (3.3 g/l) supplementation of vitamin C, leading to the result that higher supplementation of vitamin C corrected blood-brain barrier disruption and mitochondrial dysfunction. More details can be found in the study.
Kook SY, Lee KM, Kim Y, Cha MY, Kang S, Baik SH, Lee H, Park R, Mook-Jung I. High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice. Cell Death Dis. 2014 Feb 27;5:e1083.