Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients.
This study was conducted to evaluate the benefit of high-dose vitamin D supplementation in diabetic patients with cardiovascular complications. 47 patients with type 2 diabetes were assigned into two groups: Group 1 received a vitamin D supplement at a dose of 1000 U (units) per day for 12 months. Group 2 received matching placebo capsules. At the end of the study, the so-called “central aortic augmentation index”, a measure of arterial stiffness, decreased significantly in patients who received vitamin D, but did not change in the placebo group. More details can be found in the study.
Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M. Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr. 2013 Dec;32(6):970-5.