Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.
The current study analyzed the effect of vitamin D in enhancing the immune system against Mycobacterium tuberculosis, the bacterium that induces tuberculosis. It was reported that T cells (white blood cells that are important for the immune system) can fight Mycobacterium tuberculosis with the help of vitamin D. The experiment were performed with cells. The present findings underscored the importance of adequate amounts of vitamin D for reinforcing the immune system against tuberculosis. More details can be found in the study.
Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12;3(104):104ra102.