Summary Previous studies have shown a link between vitamin D deficiency and glucose metabolism disorders. This Iranian study aimed to evaluate whether vitamin D administration can manage diabetes mellitus type 1. During the study, the researchers examined the effect of vitamin D on long-term glucose (HbA1c) levels of children and adolescents with type 1 diabetes.…
Summary In this study, researchers from Iran evaluated the impact of vitamin D supplement therapy on glucose regulation in children with type 1 diabetes. In total, 30 children with type 1 diabetes and low vitamin D levels were enrolled in the study. In addition to the standard insulin therapy for diabetics, the patients also received…
Summary Iranian researchers conducted this study to determine the effects of omega-3 fatty acids and vitamin E on oxidative stress, inflammation, and pregnancy outcomes in women with gestational diabetes. 60 patients who did not take oral anti-diabetic medication were randomly allocated to take either 1000 mg of omega-3 fatty acids plus 400 IU (268 mg)…
Summary The objective of this study was to evaluate the effects of vitamin B1 (thiamin) supplementation on inflammation and oxidative stress in women with gestational diabetes mellitus. 60 patients participated in this study and were allocated to two groups that received either 100 mg/day of vitamin B1 supplements (30 patients) or a placebo (30 patients)…
Summary This study, conducted by Indian research departments, aimed to investigate the differences in dietary intake of macro- and micronutrients in elderly patients with type 2 diabetes mellitus, with and without food ulcers. Elderly type 2 diabetes patients with foot ulcers (79 patients) and type 2 diabetes patients without foot ulcers (59 patients) were studied.…
Summary This study, executed by the University of Riyadh, Saudi Arabia, investigated the relationship between vitamin D levels and the cognitive function of patients with multiple sclerosis (MS). 39 patients diagnosed with MS participated in this study. Patient information was collected and evaluated, and vitamin D levels were assessed. The researchers found that patients with…
Summary Vitamin D deficiency is associated with the incidence and prevalence of various neurologic disorders, including multiple sclerosis. This Turkish study aimed to assess the relationship of vitamin D deficiency with health-related quality of life and fatigue in MS patients. Therefore, vitamin D3 levels were measured in 149 MS patients. Patients with a vitamin D…
Summary This Iranian study aimed to assess the safety and efficacy of high-dose oral vitamin D3 in pregnant women with multiple sclerosis (MS). To this end, 15 pregnant women with MS and low vitamin D levels received either 50000 IU (1250 µg) of vitamin D3 per week or only routine care from the 12th to…
Summary Many multiple sclerosis (MS) patients are interested in alternative therapies, including dietary supplements, to reduce the severity and symptoms of the disease. This review by the Washington University in St. Louis, USA, gives an overview of vitamins and dietary supplements that play a role in MS. Several studies have pointed out that vitamin D…
Summary This Iranian study reviews the role of specific vitamins in the function of the immune system and possible therapeutic opportunities for MS patients. Vitamins with a considerable effect on the development of MS are vitamins D, B12, and B9. Additionally, vitamins A, E, and B1 can decelerate MS progression or improve unfavorable conditions like…
Summary This review, executed by Indian and American research institutes, evaluated several potential factors influencing multiple sclerosis (MS) onset and progression. Low levels of vitamin D are a major risk factor of MS. The findings from this review indicate a strong correlation between insufficient vitamin D levels and MS. Thus, the researchers conclude that dietary…
Summary This review, executed by the University of Lublin, Poland, discusses the correlation between vitamin D levels and nerve cell damage in patients with multiple sclerosis (MS). Vitamin D has been shown to decrease the onset and progression of MS. Furthermore, it has been associated with significantly lower damage to nerve cells and improved inflammation…
Summary This study, conducted by research centers and universities from Germany, Switzerland, and the USA, investigated the associations between vitamin D deficiency and multiple sclerosis (MS). In MS, the body mistakenly attacks the protective layer around the nerves in the brain and spinal cord. These damaged areas are called lesions. 53 MS patients were involved…
Summary Since depressive symptoms are common in patients with multiple sclerosis (MS) and lower vitamin D levels are often associated with depression, this study evaluated the effect of vitamin D on depressive symptoms in MS patients. 35 MS patients were included who received 10000 IU (250 µg) of vitamin D daily for 12 months. At…
Summary Depression is common in multiple sclerosis (MS) patients. This study, conducted by Jordanian research departments, aimed to investigate whether vitamin D levels correlate with depression in people with multiple sclerosis (MS). The risk of depression, vitamin D blood levels, and disability status were evaluated during the investigation. 88 patients were enrolled, of which more…
Summary This review, conducted by research departments in Greece, aimed to evaluate studies on the potential beneficial effects of dietary supplements to control symptoms and relapses in multiple sclerosis (MS) patients. Clinical trials showed that nutritional status and supplementation are potential factors affecting the risk and progression of the disease. A high prevalence of vitamin…
Summary This study, executed by medical schools in Boston, USA, explored whether magnesium intake is associated with a lower risk of diabetes type 2, especially in the context of a diet low in cereal fiber and high in low-quality carbohydrates, which provide quick energy but are mainly devoid of nutrients. Dietary magnesium intake was assessed…
Summary Since omega-3 fatty acids and curcumin have been shown to protect nerve cells from damage and suppress inflammation, a clinical trial evaluated the ability of these micronutrients to decrease a specific inflammatory substance (TNF-α) involved in migraine development. The trial was performed for 2 months and included 74 migraine patients who were divided into…
Summary Oxidative stress plays a significant role in the development of migraine. Antioxidant micronutrients have therefore been used in migraine treatment and prevention. This review, conducted by three Polish research departments, summarizes studies on micronutrients with antioxidative properties, including vitamin C, curcumin, and coenzyme Q10. The review indicates that several antioxidant micronutrients are a valuable…
Summary This study, conducted by Iranian research departments, investigated the antioxidant and anti-inflammatory effects of alpha-lipoic acid on several factors involved in clinical symptoms of migraine. 92 women with migraine participated in this trial and received either 300 mg of alpha-lipoic acid or a placebo twice daily for 3 months. Blood samples were taken and…
Summary Multiple sclerosis (MS) is associated with inflammatory processes. This Iranian study investigated the effect of coenzyme Q10 supplementation on inflammatory and anti-inflammatory parameters in patients with MS. In the study, 48 MS patients were divided into a placebo group or a supplementation receiving 500 mg of coenzyme Q10 daily. After 12 weeks, the researchers…
Summary Vitamins and trace elements are essential for a well-functioning body, and micronutrient deficiencies can lead to widespread health problems. This review, conducted by American research departments, discusses the consequences of micronutrient deficiencies in diabetes and insulin resistance. The level of micronutrients in the human body depends on many factors, like the origin and composition…
Summary This Turkish study investigated the effect of vitamin D on children’s headaches, including migraines. 147 headache patients and 69 healthy controls aged 5 to 16 years were involved in the study. Each group was divided into two subgroups based on high and low sun exposure. Several parameters, including vitamin D blood levels, were measured.…
Summary This Iranian trial aimed to assess the effect of oral high-dose vitamin D intake on the production of a pro-inflammatory substance (interleukin-17, IL-17) in multiple sclerosis (MS) patients. 94 patients diagnosed with MS were therefore divided into two groups. One group received 50,000 IU (1250 µg) of vitamin D3 every five days for 12…
Summary Multiple sclerosis, a chronic disease affecting the central nervous system, is characterized by impaired immune function and an imbalance of immune cells, which are involved in developing this disease. Vitamin A can correct this imbalance. This Iranian publication reports on the results of a clinical trial with 36 MS patients who received vitamin A…
Summary This study, conducted by the Austrian universities of Graz, Vienna, and Salzburg, investigated the suppressive effect of specific regulatory immune cells in young patients with new-onset type 1 diabetes. 30 young patients were assigned to receive vitamin D3 (70 IU/kg body weight/day) or a placebo for 12 months. The immune cells (Tregs), which are…
Summary High glucose levels result in an overproduction of free radicals, inducing oxidative stress and impairing the function of antioxidants. This trial, conducted by a research institute in India, evaluated the effect of 3 months of antioxidant supplementation in Indian children with type 1 diabetes. 90 children were allocated to three groups: 31 healthy children…
Summary Gestational diabetes and vitamin D deficiency are related to insulin resistance and an impaired function of beta cells in the pancreas which produces insulin. This study, conducted by researchers from Denmark, Malaysia, and Italy, aimed to evaluate the impact of vitamin D on the glucose metabolism of Asian women with gestational diabetes during 24-28…
Summary Alpha-lipoic acid is an antioxidant that is made naturally in the body. It serves vital functions at the cellular level, such as energy production. The aim of this study was to explore the effect of alpha-lipoic acid on gestational diabetes. To this end, 60 women with gestational diabetes were divided into a supplementation group…
Summary This study aimed to determine the effects of omega-3 fatty acids and vitamin E on blood glucose (sugar) parameters and lipid concentrations in women with gestational diabetes who did not use oral diabetes medication. The study was carried out with 60 patients. The participants were randomly allocated to a group taking omega-3 fatty acids…
Summary This study assessed the effects of a combined vitamin D and probiotic supplementation on gestational diabetes. 87 women with gestational diabetes participated in the study. They were randomly assigned to three groups receiving either vitamin D plus probiotics (30 women), only probiotics (29 women), or a placebo (28 women) for 6 weeks. Vitamin D…
Summary Researchers from Iran studied the effects of a supplement containing different micronutrients (magnesium, zinc, calcium, and vitamin D) on blood glucose (sugar) levels and cardiometabolic risk factors in patients with gestational diabetes mellitus. 60 patients, aged 18 to 40 years, were divided into two groups of each 30 participants who received either the supplement…
Summary This trial, executed by three Indian research departments, aimed to assess the effects of vitamin D and calcium on metabolic factors and oxidative stress levels in women with gestational diabetes. The trial was conducted on 70 women diagnosed with gestational diabetes who received either 1000 IU (25 µg) of vitamin D and 1000 mg…
Summary Magnesium and vitamin E exert multiple beneficial effects on glucose (sugar) and lipid (fat) metabolism. This study, executed by Iranian researchers, aimed to determine the effects of magnesium and vitamin E on the metabolism of women with gestational diabetes. This study was conducted with 60 subjects diagnosed with gestational diabetes, aged 18 to 40…
Summary Vitamin D deficiency is prevalent in adolescents with type 1 diabetes and is associated with diabetes-related vascular complaints in adulthood. This trial, conducted by research departments from Canada and Israel, aimed to assess the efficacy of vitamin D treatment on the function of blood vessels and indicators of kidney-related inflammation in this patient group.…
Summary This Indian study aimed to assess the efficacy, tolerability, and safety of vitamin K in patients with peripheral neuropathy (conditions that involve damage to nerves outside of the central nervous system). The study was conducted on 100 patients with peripheral neuropathy who suffered from vitamin B12 deficiency or type 2 diabetes mellitus. The patients…
Summary This study, conducted by North American and European research departments, aimed to assess the association between vitamin D levels and multiple sclerosis (MS) development. In MS, the body mistakenly attacks the protective layer around the nerves in the brain and spinal cord. These damaged areas are called lesions. Low vitamin D levels have been…
Summary Magnesium is a micronutrient with several benefits, including anti-inflammatory properties. This study, executed by Iranian and Canadian universities, aimed to evaluate the effects of magnesium supplementation on inflammatory processes and pregnancy outcomes in women diagnosed with gestational diabetes. The trial was conducted with 36 women, 18 to 40 years old, who were allocated to…
Summary Research shows that oxidative stress and inflammation are important factors in diabetes. This study, executed by universities from Iran and Canada, aimed to determine whether supplements containing magnesium, zinc, calcium, and vitamin D can improve inflammation and oxidative stress in women with gestational diabetes. 60 patients with gestational diabetes were assigned to take the…
Summary This Iranian trial was executed to investigate the effects of alpha-lipoic acid supplementation on oxidative stress in women with gestational diabetes. 60 women with gestational diabetes at 24 to 28 weeks of pregnancy were selected and divided into a supplementation group (30 women), receiving 300 mg/day of alpha-lipoic acid for 8 weeks, and a…
Summary This review summarized current knowledge on the effect of vitamin D on type 1 and type 2 diabetes mellitus and on vascular complications associated with this disease. Several studies have provided evidence for the role of vitamin D in diabetes mellitus and found a potential link between low vitamin D levels and diabetes. More…
Summary Vitamin D deficiency is associated with a greater risk of developing type 2 diabetes mellitus. This study, executed by a research department in London, UK, determined the effect of a vitamin D and calcium replacement therapy on regulating glucose levels in Asian patients with type 2 diabetes mellitus and low vitamin D levels. The…
Summary This study, executed by a research department in Tehran, Iran, aimed to determine if micronutrients can improve neuropathy indicators in type 2 diabetes. 75 patients with type 2 diabetes were assigned to one of the following three treatment groups: The first group received a combination of zinc (20 mg), magnesium (250 mg), vitamin C…
Summary Diets and lifestyles in developed countries promote deficiencies of micronutrients, particularly vitamin C and D, and are associated with diabetes, for instance. This Australian review evaluated results from studies examining the potential of vitamin C and D in reversing defects in glucose regulation and preventing type 2 diabetes. Several studies suggest an association between…
Summary Several studies have shown that magnesium intake decreases the risk of type 2 diabetes. In this Japanese study, the association between magnesium intake and the incidence of type 2 diabetes was examined. Almost 2000 subjects without diabetes, aged between 40 and 79 years, underwent a glucose test and were followed up for 15.6 years.…
Summary Turkish research departments investigated whether migraine in children is associated with vitamin D deficiency. An additional focus of this study was the effect of vitamin D on the frequency, duration, and severity of migraine attacks. 92 children with migraine were divided into two groups: Patients with low vitamin D levels who received a vitamin…
Summary To investigate the effects of vitamin D supplementation on migraine symptoms, 65 migraine patients aged 10 to 61 years were enrolled in a study. Vitamin D was administered to 33 patients for 10 weeks with a dosage of 50,000 IU (1250 µg) of vitamin D per week. The other 32 patients received a placebo.…
Summary This review, conducted by researchers from the Medical University of Tokyo, Japan, explored the effects of vitamin B2 on migraine. Inflammation of the nervous tissue and increased oxidative stress levels play an important role in migraine. Studies have shown that vitamin B2, also named riboflavin, has anti-inflammatory properties and can protect the body against…
Summary Vitamin B2 has shown positive effects in adult migraine patients. To investigate the effectiveness of vitamin B2 in younger patients, 68 children with migraine received 10 or 40 mg of vitamin B2 per day. Average migraine frequency per month was evaluated before the study and after 3 months of vitamin B2 therapy. The results…
Summary This review, conducted by the University of Birmingham, UK, summarizes the role of metabolism in the development of migraine and migraine susceptibility. Studies have shown that a well-functioning metabolism is essential in connection with this condition, which is caused by abnormal brain activity. Micronutrients such as magnesium, coenzyme Q10, and vitamin B2 are required…