Blood levels of trace metals and amyotrophic lateral sclerosis

Summary This case-control study examined blood levels of trace metals in amyotrophic lateral sclerosis (ALS). The researchers found that selenium and zinc were inversely associated with ALS, particularly among patients with worse function, suggesting that supplementation with these nutrients may benefit such patients. Further details can be found in the study. References Arch Med Res.…

Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study

Summary This double-blind trial compared the effects of the methylcobalamin form of vitamin B12 on muscle function in amyotrophic lateral sclerosis (ALS) patients when given intramuscularly in ultrahigh-dose (25 mg/day) and low-dose (0.5 mg/day) for 14 days. The researchers found that ultrahigh-dose intramuscular injection of methylcobalamin may provide a clinically useful measure to improve or…

Fruit and vegetable intake and risk of amyotrophic lateral sclerosis in Japan

Summary This study investigated the relationship between dietary intake of vegetables, fruit, and antioxidants and the risk of amyotrophic lateral sclerosis (ALS). Its findings suggest that higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS. Further details can be found in the study. References Sheweita…

Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis

Summary This study was based on a food-frequency questionnaire and assessed whether dietary intake of fatty acids, cholesterol, glutamate or antioxidants was associated with the risk of developing amyotrophic lateral sclerosis (ALS). The researchers concluded that a high intake of polyunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing…

Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies

Summary This study investigated the risk of amyotrophic lateral sclerosis (ALS) by analyzing 5 studies involving a total of over 1.1 million participants. The researchers found that consumption of foods high in carotenoids may help prevent or delay onset of ALS. Further details can be found in the study. References Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky…

Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis

Summary This study reports that a severe vitamin D deficiency in amyotrophic lateral sclerosis (ALS) patients accelerates the rate of decline by 4 times and is associated with a marked shorter life expectancy. The researchers say their findings support a neuroprotective function of vitamin D on motoneurons and propose vitamin D as a reliable prognostic…

Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies

Summary This study examined 5 earlier studies and investigated whether vitamin E intake was associated with amyotrophic lateral sclerosis (ALS). The researchers found that long-term vitamin E supplement use was associated with lower ALS rates and concluded that a possible protective effect of vitamin E in this disease deserves further consideration. Further details can be…

The therapeutic potential of folic acid to treat amyotrophic lateral sclerosis (ALS)

Summary This study analyzed the link between familial amyotrophic lateral sclerosis (fALS), a common degenerative disease of the motor neuron system, and folic acid (FA). Mutations of the enzyme superoxide dismutase (SOD1) are involved in the development of this disease. Using a mice model, the present study demonstrated that SOD1 alteration leads to an increase…