Summary Multiple sclerosis (MS) is associated with inflammatory processes. This Iranian study investigated the effect of coenzyme Q10 supplementation on inflammatory and anti-inflammatory parameters in patients with MS. In the study, 48 MS patients were divided into a placebo group or a supplementation receiving 500 mg of coenzyme Q10 daily. After 12 weeks, the researchers…
Summary Since depressive symptoms are common in patients with multiple sclerosis (MS) and lower vitamin D levels are often associated with depression, this study evaluated the effect of vitamin D on depressive symptoms in MS patients. 35 MS patients were included who received 10000 IU (250 µg) of vitamin D daily for 12 months. At…
Summary This study, conducted by research centers and universities from Germany, Switzerland, and the USA, investigated the associations between vitamin D deficiency and multiple sclerosis (MS). In MS, the body mistakenly attacks the protective layer around the nerves in the brain and spinal cord. These damaged areas are called lesions. 53 MS patients were involved…
Summary This review, executed by the University of Lublin, Poland, discusses the correlation between vitamin D levels and nerve cell damage in patients with multiple sclerosis (MS). Vitamin D has been shown to decrease the onset and progression of MS. Furthermore, it has been associated with significantly lower damage to nerve cells and improved inflammation…
Summary This review, executed by Indian and American research institutes, evaluated several potential factors influencing multiple sclerosis (MS) onset and progression. Low levels of vitamin D are a major risk factor of MS. The findings from this review indicate a strong correlation between insufficient vitamin D levels and MS. Thus, the researchers conclude that dietary…
Summary This Iranian study reviews the role of specific vitamins in the function of the immune system and possible therapeutic opportunities for MS patients. Vitamins with a considerable effect on the development of MS are vitamins D, B12, and B9. Additionally, vitamins A, E, and B1 can decelerate MS progression or improve unfavorable conditions like…
Summary Many multiple sclerosis (MS) patients are interested in alternative therapies, including dietary supplements, to reduce the severity and symptoms of the disease. This review by the Washington University in St. Louis, USA, gives an overview of vitamins and dietary supplements that play a role in MS. Several studies have pointed out that vitamin D…
Summary This Iranian study aimed to assess the safety and efficacy of high-dose oral vitamin D3 in pregnant women with multiple sclerosis (MS). To this end, 15 pregnant women with MS and low vitamin D levels received either 50000 IU (1250 µg) of vitamin D3 per week or only routine care from the 12th to…
Summary Vitamin D deficiency is associated with the incidence and prevalence of various neurologic disorders, including multiple sclerosis. This Turkish study aimed to assess the relationship of vitamin D deficiency with health-related quality of life and fatigue in MS patients. Therefore, vitamin D3 levels were measured in 149 MS patients. Patients with a vitamin D…
Summary This study, executed by the University of Riyadh, Saudi Arabia, investigated the relationship between vitamin D levels and the cognitive function of patients with multiple sclerosis (MS). 39 patients diagnosed with MS participated in this study. Patient information was collected and evaluated, and vitamin D levels were assessed. The researchers found that patients with…
Summary Depression is common in multiple sclerosis (MS) patients. This study, conducted by Jordanian research departments, aimed to investigate whether vitamin D levels correlate with depression in people with multiple sclerosis (MS). The risk of depression, vitamin D blood levels, and disability status were evaluated during the investigation. 88 patients were enrolled, of which more…
Summary This review, conducted by research departments in Greece, aimed to evaluate studies on the potential beneficial effects of dietary supplements to control symptoms and relapses in multiple sclerosis (MS) patients. Clinical trials showed that nutritional status and supplementation are potential factors affecting the risk and progression of the disease. A high prevalence of vitamin…
Summary Multiple sclerosis, a chronic disease affecting the central nervous system, is characterized by impaired immune function and an imbalance of immune cells, which are involved in developing this disease. Vitamin A can correct this imbalance. This Iranian publication reports on the results of a clinical trial with 36 MS patients who received vitamin A…
Summary This Iranian trial aimed to assess the effect of oral high-dose vitamin D intake on the production of a pro-inflammatory substance (interleukin-17, IL-17) in multiple sclerosis (MS) patients. 94 patients diagnosed with MS were therefore divided into two groups. One group received 50,000 IU (1250 µg) of vitamin D3 every five days for 12…
Summary This study, conducted by North American and European research departments, aimed to assess the association between vitamin D levels and multiple sclerosis (MS) development. In MS, the body mistakenly attacks the protective layer around the nerves in the brain and spinal cord. These damaged areas are called lesions. Low vitamin D levels have been…
Summary Fatigue and depression are common symptoms of multiple sclerosis (MS). Therefore, the present study aimed to investigate the effect of coenzyme Q10 supplementation on these symptoms. A significant decrease in fatigue and depression was observed in patients who received 500 mg of coenzyme Q10 per day. In contrast, there was a considerable increase in…
Summary The objective of this study was to assess the clinical efficacy and safety of high doses of biotin (vitamin B7) in patients suffering from progressive multiple sclerosis (MS). 23 patients with this nervous system disease were treated with 100 to 300 mg of biotin daily for up to 3 years. The results showed significant…
Summary Fatigue is one of the most common and disabling multiple sclerosis (MS) symptoms. However, there is no effective medication for this symptom. Therefore, this Israelian study aimed to evaluate the effect of a specific vitamin D supplement (alfacalcidol) on MS-related fatigue. 158 patients with significant fatigue were included and received the supplement (1µg/day) or…
Summary Low vitamin D levels have been associated with worse outcomes in multiple sclerosis (MS) patients. Therefore, researchers from Finland, Switzerland, and the USA investigated whether vitamin D supplementation can improve the health of patients suffering from MS. The results showed improved outcomes following the vitamin D treatment, including less tissue damage in the group…
Summary This study, conducted by the University of Rome, Italy, aimed to investigate the potential neuroprotective effects of vitamins B1, B6, and B12 in multiple sclerosis patients. 16 patients were involved and treated with oral nutritional supplements containing 300 mg of vitamin B1, 450 mg of vitamin B6 and 1500 µg of vitamin B12 for…
Summary This study explored the effect of high-dose vitamin D intake on the quality of life in patients with multiple sclerosis. 94 patients with multiple sclerosis were allocated to two groups: The first group received 50000 IU (1250 µg) of vitamin D3 every five days for 3 months. The second group received a placebo. The…
Summary Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Anti-inflammatory drugs are among the medicines used to treat MS. In the present study, an Iranian research department evaluated the effect of high-dose vitamin D on a potent anti-inflammatory cytokine (protein), IL-10, in patients with multiple sclerosis. 94 MS patients were…
Summary Multiple sclerosis is associated with vitamin D deficiency and cognitive impairment. This clinical trial, conducted by the University of Beirut, Lebanon, evaluated the cognitive performance in vitamin D-deficient MS patients and its potential improvement after 3 months of vitamin D3 intake. 88 MS patients were enrolled. The researchers found that vitamin D3 supplementation improved…
Summary This study, conducted by the Oregon Health and Science University and the Colorado State University in the USA, aimed to evaluate the effects of the antioxidant lipoic acid on gait and balance in multiple sclerosis patients. The study participants took 1200 mg of oral lipoic acid or a placebo for 2 years. Walking performance,…
Summary This study aimed to determine the impact of vitamin A on disease progression in multiple sclerosis (MS) patients. 101 MS patients participated in this study, which lasted one year. The treatment group received a supplement containing 25000 IU (7500 µg) of vitamin A for 6 months daily, followed by 10000 IU (3000 µg) of…
Summary This Iranian study aimed to determine whether vitamin A supplementation can improve psychiatric health in multiple sclerosis (MS) patients. 101 MS patients were enrolled in this study and allocated to a treatment or placebo group. The treatment group was administered 25000 IU (7500 µg) of vitamin A per day for 6 months, followed by…
Summary Patients with multiple sclerosis (MS) are characterized by problems to perform activities of daily living and walking difficulties, among others. To test whether micronutrient supplementation can improve these symptoms, 51 MS patients received either 20 ml of a dietary formula (containing omega-3 and omega-6 fatty acids, vitamin A, and vitamin E) or 20 ml…
Summary Can vitamin D3 supplements improve the immune system of patients with multiple sclerosis (MS)? To shed light on this question, 40 MS patients received a high-dose vitamin D3 supplement containing 10,400 IU (260 µg) of vitamin D3 or a lower-dose supplement with 800 IU (20 µg) of vitamin D3 daily for 6 months. It…