This trial, executed by several Iranian research departments, aimed to assess the effects of folic acid alone and in combination with vitamin B6 on migraine attacks in adult migraine patients with aura (i.e., sensory disturbances including flashes of light, blind spots, and other vision changes). During this trial, 95 Iranian migraine patients with aura, aged 18 to 65 years, received folic acid (5 mg/day) plus vitamin B6 (80 mg/day), folic acid alone (5 mg/day), or a placebo for 3 months. The characteristics of migraine attacks were determined at the study’s start and end. The study concluded that supplementation with folic acid and vitamin B6 significantly decreased headache severity and attack frequency compared to the placebo group. Please see the study for more details.


Askari et al.


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