The therapeutic potential of folic acid to treat amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis

Summary This study analyzed the link between familial amyotrophic lateral sclerosis (fALS), a common degenerative disease of the motor neuron system, and folic acid (FA). Mutations of the enzyme superoxide dismutase (SOD1) are involved in the development of this disease. Using a mice model, the present study demonstrated that SOD1 alteration leads to an increase…