Researchers from the School of Public Health at Curtin University in Perth, Australia, assessed the effects of high-dose vitamin B1 (thiamine) supplementation on blood pressure and lipid and inflammation parameters in people with impaired glucose metabolism. 12 participants with high blood glucose levels received both a placebo and thiamine capsules (3 x 100 mg/day) for 6 weeks sequentially. Among others, systolic (upper) and diastolic (lower) blood pressure, lipid parameters, inflammation, and thiamine levels were evaluated at the start, after three weeks, and on the completion of intake. Among others, the research team found a decreased diastolic (lower) blood pressure in participants consuming thiamine supplements compared with measurements at the start of the study and after 3 weeks. No significant change was observed in participants receiving a placebo. In conclusion, high-dose thiamine supplementation seems to have a role in vascular health. More details can be found in the study.
Alaei-Shahmiri et al.