Since depressive symptoms are common in patients with multiple sclerosis (MS) and lower vitamin D levels are often associated with depression, this study evaluated the effect of vitamin D on depressive symptoms in MS patients. 35 MS patients were included who received 10000 IU (250 µg) of vitamin D daily for 12 months. At the start of the study, vitamin D levels were low in participants, and depressive symptoms were high. After vitamin D replacement and during follow-up, depressive symptoms improved. The results showed, in conclusion, that lower vitamin D levels are associated with higher depression, and vitamin D treatment improved depressive symptoms in patients with MS. More details can be found in the study.
Kotb et al.