This study was undertaken to clarify the mechanism of the antihypertensive effect of coenzyme Q10 (CoQ10). Twenty-six patients with essential arterial hypertension were treated with oral CoQ10, 50 mg twice daily for 10 weeks. Plasma CoQ10, serum total and high-density lipoprotein (HDL) cholesterol, and blood pressure were determined in all patients before and at the end of the 10-week period. At the end of the treatment, systolic blood pressure (SBP) decreased from 164.5 +\/- 3.1 to 146.7 +\/- 4.1 mmHg and diastolic blood pressure (DBP) decreased from 98.1 +\/- 1.7 to 86.1 +\/- 1.3 mmHg (P < 0.001). Plasma CoQ10 values increased from 0.64 +\/- 0.1 microgram\/ml to 1.61 +\/- 0.3 micrograms\/ml (P < 0.02). Serum total cholesterol decreased from 222.9 +\/- 13 mg\/dl to 213.3 +\/- 12 mg\/dl (P < 0.005) and serum HDL cholesterol increased from 41.1 +\/- 1.5 mg\/dl to 43.1 +\/- 1.5 mg\/dl (P < 0.01). In a first group of 10 patients serum sodium and potassium, plasma clinostatic and orthostatic renin activity, urinary aldosterone, 24-hour sodium and potassium were determined before and at the end of the 10-week period. In five of these patients peripheral resistances were evaluated with radionuclide angiocardiography. Total peripheral resistances were 2,283 +\/- 88 dyne.s.cm-5 before treatment and 1,627 +\/- 158 dyn.s.cm-5 after treatment (P < 0.02). Plasma renin activity, serum and urinary sodium and potassium, and urinary aldosterone did not change. In a second group of 11 patients, plasma endothelin, electrocardiogram, two-dimensional echocardiogram and 24-hour automatic blood pressure monitoring were determined.\n\n\n
V Digiesi,\u00a0F Cantini,\u00a0A Oradei,\u00a0G Bisi,\u00a0G C Guarino,\u00a0A Brocchi,\u00a0F Bellandi,\u00a0M Mancini,\u00a0G P Littarru<\/p>\n
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Summary This study was undertaken to clarify the mechanism of the antihypertensive effect of coenzyme Q10 (CoQ10). Twenty-six patients with essential arterial hypertension were treated with oral CoQ10, 50 mg twice daily for 10 weeks. Plasma CoQ10, serum total and high-density lipoprotein (HDL) cholesterol, and blood pressure were determined in all patients before and at…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[527],"_links":{"self":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts\/6582"}],"collection":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/comments?post=6582"}],"version-history":[{"count":1,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts\/6582\/revisions"}],"predecessor-version":[{"id":6904,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts\/6582\/revisions\/6904"}],"wp:attachment":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/media?parent=6582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/categories?post=6582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/tags?post=6582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}