Background: Fruit and vegetable intake has been associated with lower risk for cardiovascular risk factors and disease. Data on its association with atrial fibrillation are lacking. Methods and results: We examined the prospective association of plasma vitamin C concentration as a biomarker for fruit and vegetable intake with the risk of hospitalisation with diagnosis of atrial fibrillation in apparently healthy 8,760 men and 10,530 women aged 39\u201379 participating in the EPIC-study in Norfolk. The hazard ratios of atrial fibrillation comparing each quartile of plasma vitamin C concentration with the lowest were 0.76 (95% CI 0.57\u20131.00), 0.73 (95% CI 0.55\u20130.98) and 0.77 (95% CI 0.58\u20131.01) in women (p for trend 0.05) and 0.81 (95% CI 0.63\u20131.03), 0.96 (95% CI 0.76\u20131.22) and 1.01 (95% CI 0.79\u20131.28) in men (p for trend 0.66) after adjustment for age, smoking, alcohol consumption, physical activity, systolic blood pressure, diabetes, use of blood pressure medication and body-mass index, with a significant gender \u00d7 vitamin C interaction (p = 0.03). Assuming a linear association, a 20 \u03bcmol\/l increase in plasma vitamin C concentration (1 standard deviation) was associated with a 13% (95% CI 3\u201322%) relative reduction in risk of atrial fibrillation in women. Conclusion: Plasma vitamin C was inversely associated with the risk of atrial fibrillation in women, but there was no such association in men. Our findings suggest that intake of food rich in vitamin C might be preventive for atrial fibrillation with a significant benefit particularly in women with low baseline intake.<\/p>\n
Pfister R, Michels G, Br\u00e4gelmann J, Sharp SJ, Luben R, Wareham NJ, Khaw KT.<\/p>\n
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Summary Background: Fruit and vegetable intake has been associated with lower risk for cardiovascular risk factors and disease. Data on its association with atrial fibrillation are lacking. Methods and results: We examined the prospective association of plasma vitamin C concentration as a biomarker for fruit and vegetable intake with the risk of hospitalisation with diagnosis…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[1898,1899,1901,1900,1897],"_links":{"self":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts\/7268"}],"collection":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/comments?post=7268"}],"version-history":[{"count":0,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/posts\/7268\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/media?parent=7268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/categories?post=7268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthlibrary.info\/wp-json\/wp\/v2\/tags?post=7268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}