Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study

Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study

This double-blind trial compared the effects of the methylcobalamin form of vitamin B12 on muscle function in amyotrophic lateral sclerosis (ALS) patients when given intramuscularly in ultrahigh-dose (25 mg/day) and low-dose (0.5 mg/day) for 14 days.
The researchers found that ultrahigh-dose intramuscular injection of methylcobalamin may provide a clinically useful measure to improve or retard muscle wasting in ALS patients.

Further details can be found in the study.
Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J.
Muscle Nerve. 1998 Dec;21(12):1775-8.

Leave a Reply