Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study

Summary

This double-blind trial compared the effects of the methylcobalamin form of vitamin B12 on muscle function in amyotrophic lateral sclerosis (ALS) patients when given intramuscularly in ultrahigh-dose (25 mg/day) and low-dose (0.5 mg/day) for 14 days.
The researchers found that ultrahigh-dose intramuscular injection of methylcobalamin may provide a clinically useful measure to improve or retard muscle wasting in ALS patients.

Further details can be found in the study.

References

Z Shemesh, J Attias, M Ornan, N Shapira, A Shahar

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