Green tea extract prevents HIV infection

How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors.

This study evaluated the effectiveness of epigallocatechin gallate (EGCG), a green tea compound, against human immunodeficiency virus (HIV) infection. The experiments confirmed that EGCG is effective in inhibiting CD4-gp120 binding, which is the initial step of HIV entry into the cells. In the first stage of infection HIV attacks CD4 cells that normally support the immune system function. The interaction between HIV and CD4 cells is made possible by the so called gp120 molecule that is part of the virus and binds to CD4 cells at a specific site. This process can be inhibited if another molecule binds to CD4 at the same site as gp120. The experiments demonstrated that EGCG bound to CD4 at the gp120 binding site, thereby inhibiting the progression of HIV infection. The results confirmed that EGCG can be effective against HIV infection. More details can be found in the study.
Hamza A, Zhan CG. How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors. J Phys Chem B. 2006 Feb 16;110(6):2910-7.


Leave a Reply