Oxidative damage and progression to Alzheimer's disease in patients with mild cognitive impairment.
Oxidative stress is an imbalance between the production of free radicals and the ability of the body to counteract their harmful effects through neutralization by antioxidants (i.e. vitamin E). The present study evaluated whether oxidative stress has a role in the progression of cognitive impairment to Alzheimer's disease. Data from 70 patients with mild cognitive impairment (MCI) were analyzed. MCI is described as an intermediate stage between the expected cognitive (mental) decline of normal aging and the more serious decline of dementia. The results of the study provided evidence that the progression to Alzheimer's disease can be related to a decrease in antioxidants in blood, such as vitamin E. For further details please refer to the study.
Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D, Oliveira CR. Oxidative damage and progression to Alzheimer's disease in patients with mild cognitive impairment. J Alzheimers Dis. 2010;21(4):1165-77.