Reduced vitamin C levels are associated with inflammation

Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis.

This study evaluated the association between vitamin C levels and peripheral arterial disease (PAD). PAD is a severe atherosclerotic condition frequently accompanied by inflammation. Vitamin C levels were analyzed in 85 PAD patients, 106 hypertensive (high blood pressure) patients without PAD and 113 healthy individuals. C-reactive protein (CRP) concentrations (marker for inflammation) were also evaluated. The results showed that low vitamin C levels were associated with inflammation and higher CRP levels in PAD patients. Further details can be found in the study.
Langlois M, Duprez D, Delanghe J, De Buyzere M, Clement DL. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation. 2001 Apr 10;103(14):1863-8.



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