Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: role of AGE-RAGE* signaling.
The present study examined the beneficial effects of the natural compound resveratrol on diabetic changes of blood vessel walls (diabetic vasculopathy). The study was conducted with rats suffering from (artificially induced) diabetes. In the study, the animals were treated with or without resveratrol (at 0.75 mg/kg body weight) three times a day for 4-8 weeks. In resveratrol-treated rats, several vascular conditions, i.e. vascular wall thickening and vascular permeability (the capacity of a blood vessel wall to allow for the flow of small molecules in and out of the vessel), were all alleviated. In comparison, no improvements were detected in rats without resveratrol supplementation. The findings led to the conclusion that resveratrol reduces diabetes-induced vasculopathy. More details can be found in the study.
Jing YH, Chen KH, Yang SH, Kuo PC, Chen JK. Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: role of AGE-RAGE signalling. Diabetes Metab Res Rev. 2010 Mar;26(3):212-22.