Fatigue is one of the most common and disabling multiple sclerosis (MS) symptoms. However, there is no effective medication for this symptom. Therefore, this Israelian study aimed to evaluate the effect of a specific vitamin D supplement (alfacalcidol) on MS-related fatigue. 158 patients with significant fatigue were included and received the supplement (1µg/day) or a placebo for 6 consecutive months. Patients who were administered the vitamin D supplement showed a decreased level of fatigue, which also resulted in an improved quality of life in these patients. Additionally, patients in the treatment group experienced fewer recurrences of their fatigue. No side effects were observed. This study showed that vitamin D is a safe and effective treatment strategy to decrease fatigue and improve the quality of life in MS patients. Further details can be found in the study.


Achiron et al.


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